Publications

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Books

  1. D.J. Burgess. Injectable Dispersed Systems, Formulation, Processing and Performance. Ed. D.J. Burgess, Drugs and The Pharmaceutical Sciences Series, Marcel Dekker, New York, (2005).
  2. J. Wright and D.J. Burgess: Controlled Release Science and Technology: Long Acting Injections and Implants, CRS Press, Springer, New York, 2012 http://dx.doi.org/10.1007/978-1-4614-0554-2

Recent Articles

  1. S. Fanse, D.J. Burgess. In vitro- in vivo relationship and microstructural insights into long-acting levonorgestrel intrauterine systems. J. Controlled release. 2025, 383:113858. https://doi.org/10.1016/j.jconrel.2025.113858 
  2. L. Burroughs, D.J. Burgess. How could the affordable, reliable and continuous production of lipid nanoparticles revolutionize healthcare? Nanomedicine. 2025. https://doi.org/10.1080/17435889.2025.2500911 
  3. A. Abhang, D.J. Burgess. Recent advancements and future applications of intrauterine drug delivery systems. Expert Opinion on Drug Delivery. 2025. https://doi.org/10.1080/17425247.2025.2490266 
  4. X. Wang, R. Wang, M. Roy, Y. Wang, B. Qin, D.J. Burgess. Understanding drug release mechanisms of risperidone in situ forming implant depots in rabbits. J. Controlled Release. 2025, 383:113785. https://doi.org/10.1016/j.jconrel.2025.113785 
  5. A.G. Clark, J. Wong, R. Wang, Y. Wang, B. Qin, D.J. Burgess, S. Zhang. Aging-induced microstructural evolution in risperidone loaded PLGA microspheres. Int. J. Pharmaceutics. 2025, 675 125512. https://doi.org/10.1016/j.ijpharm.2025.125512 
  6. E. Duran, P. Romero-Hasler, M.G.V. Sarmiento, G. Alvarez-Acevedo, E. Soto-Bustamante, A. Neira-Carrillo, F. Oyarzun-Ampuero, D.J. Burgess, C. Valenzuela, C.V. Venegas. Iron dextran-loaded alginate-calcium multi-vesicular microparticles as an intramuscular supplement: a new approach for in situ prolonged iron release. Food Structure. 2025, 43 100411. https://doi.org/10.1016/j.foostr.2025.100411 
  7. X. Wang, R. Wang, M. Roy, O. Kwok, D.J. Burgess. Long-acting injectable in situ forming implants: Impact of polymer attributes and API. Int. J. Pharmaceutics. 2025, 670:125080. https://doi.org/10.1016/j.ijpharm.2024.125080 
  8. D.A. Silva, M.L. Merdy, K.D. Alam, Y. Wang, Q. Bao, N. Malavia, D.J. Burgess and V. Lukacova. Development of mechanistic in vitro–in vivo extrapolation to support bioequivalence assessment of long-acting injectables. Pharmaceutics 2024, 16, 552. https://doi.org/10.3390/pharmaceutics16040552 
  9. N. Malavia, Q. Bao, D.A. Silva, Y. Wang, K. Alam, V. Lukacova, D.J. Burgess. Impact of agglomeration on in vitro performance of long-acting injectable suspensions. Int. J. Pharmaceutics. 2024, 673:125390. https://doi.org/10.1016/j.ijpharm.2025.125390 
  10. N. Malavia, Q. Bao, D.J. Burgess, Novel dissolution methods for drug release testing of Long-Acting injectables. Int. J. Pharm. 2024, 664:0378-5173. https://doi.org/10.1016/j.ijpharm.2024.124634
  11. S. Kharea, R. Jog, A. Bright, D.J. Burgess, S.K. Chakder and K. Gokulan. Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats. Nanotoxicology. 2023,17(10):583-603. https://doi.org/10.1080/17435390.2023.2289940
  12. Y. Huang, S. Liangpunsakul, S. Rudraiah, J. Ma, S.K. Keshipeddy, D. Wright, A. Costa, D.J. Burgess, Y. Zhang, N. Huda, L. Wang, Z. Yang. HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis. Hepatol Commun. 7(11):e0299,Nov. 2023. https://doi.org/10.1097/HC9.0000000000000299
  13. X. Wang, Q. Bao, R. Wang, O. Kwok, K. Maurus, Y. Wang, B. Qin, D.J. Burgess. In situ forming risperidone implants: Effect of PLGA attributes on product performance. J. Controlled Release., 2023, 361:777-791. https://doi.org/10.1016/j.jconrel.2023.08.029
  14. X. Wang, Q. Bao, R. Wang, T. Li, Y. Wang, B. Qin, Q. Li, D.J. Burgess. In vivo characterization of Perseris and compositionally equivalent formulations. Int. J. Pharm. 2023, 642:123170. https://doi.org/10.1016/j.ijpharm.2023.123170
  15. A.G. Clark, R. Wang, J. Lomeo, Y. Wang, A. Zhu, M. Shen, Q. Bao, D.J. Burgess, B. Qin, S. Zhang. Investigating structural attributes of drug encapsulated microspheres with quantitative X-ray imaging. J. Controlled Release. 2023, 358:626-635. https://doi.org/10.1016/j.jconrel.2023.05.019
  16. B. Wan, Q. Bao, D.J. Burgess. Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product understanding. Advanced Drug Delivery Reviews. 2023, 198:114857. https://doi.org/10.1016/j.addr.2023.114857
  17. X. Wang, Q. Bao, R. Wang, B. Wan, Y. Wang, B. Qin, D.J. Burgess. Reverse engineering of Perseris and development of compositionally equivalent formulations. Int. J. Pharm. 2023, 639: 122948. https://doi.org/10.1016/j.ijpharm.2023.122948 hk
  18. R. Holm, R.W. Lee, J. Glassco, N. DiFranco, Q. Bao, D.J. Burgess, V. Lukacova, S. Alidori. Long-acting injectable aqueous suspensions – Summary from an AAPS workshop. AAPS J. 2023, 25(3):49. doi: 10.1208/s12248-023-00811-8
  19. Q. Bao, X. Wang, B. Wan, Y. Zou, Y. Wang, D.J. Burgess. Development of in vitro-in vivo correlations for long-acting injectable suspensions. Int. J. Pharm. 2023, 634:122642. https://doi.org/10.1016/j.ijpharm.2023.122642
  20. R.H. Gudlavalleti, X. Xi, A. Legassey, P.Y. Chan, J. Li, D.J. Burgess, C. Giardina, F. Papadimitrakopoulos and F. Jain. Highly Miniaturized, Low-Power CMOS ASIC Chip for Long-Term Continuous Glucose Monitoring. Journal of Diabetes Science and Technology. 2023, Feb 11:19322968231153419. https://doi.org/10.1177/19322968231153419
  21. R. Kulkarni, S. Fanse, D.J. Burgess. Mucoadhesive drug delivery systems: a promising non-invasive approach to bioavailability enhancement. Part I: biophysical considerations. Expert Opinion on Drug Delivery. 2023, 20(3):395-412. https://doi.org/10.1080/17425247.2023.2181331
  22. R. Kulkarni, S. Fanse, D.J. Burgess. Mucoadhesive drug delivery systems: a promising non-invasive approach to bioavailability enhancement. Part II: formulation considerations. Expert Opinion on Drug Delivery. 2023, 20(3):413-434. https://doi.org/10.1080/17425247.2023.2181332
  23. Q. Bao, S. Fanse, X. Lu, D.J. Burgess. Impact of drug loading on release from levonorgestrel intrauterine systems. Int. J. Pharm. 2022, 631:122532. https://doi.org/10.1016/j.ijpharm.2022.122532
  24. S. Fanse, Q. Bao, D.J. Burgess. Long-acting intrauterine systems: Recent advances, current challenges, and future opportunities. 2022, Advanced Drug Delivery Reviews, 191:114581. https://doi.org/10.1016/j.addr.2022.114581
  25. X. Wang, Q. Bao, A.G. Clark, Y. Wang, S. Zhang, D.J. Burgess. Characterization and in vitro release of minocycline hydrochloride microspheres prepared via coacervation. Int. J. Pharm. 2022, 628:122292. https://doi.org/10.1016/j.ijpharm.2022.122292
  26. A.G. Clark, R. Wang, Y. Qin, Y. Wang, A. Zhu, J. Lomeo, Q. Bao, D.J. Burgess, J. Chen, B. Qin, Y. Zou, S. Zhang. Assessing microstructural critical quality attributes in PLGA microspheres by FIB-SEM analytics. J. Controlled Release. 2022, 349:580–591. https://doi.org/10.1016/j.jconrel.2022.06.066
  27. Wan, Q. Bao, R. Wang, D.J. Burgess. Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLG microspheres. Int. J. Pharm. 2022, 625:122032. https://doi.org/10.1016/j.ijpharm.2022.122032
  28. Wang, Q. Bao, M.S. Suh, M. Kastellorizios, R. Wang, D.J. Burgess. Novel adapter method for in vitro release testing of in situ forming implants. Int. J. Pharm. 2022, 621:121777. https://doi.org/10.1016/j.ijpharm.2022.121777
  29. Bao, X. Wang, Y. Zou, Y. Wang, D.J. Burgess. In vitro release testing method development for long-acting injectable suspensions. Int. J. Pharm. 2022, 622:121840. https://doi.org/10.1016/j.ijpharm.2022.121840
  30. Wan, Q. Bao, D.J. Burgess. In vitro-in vivo correlation of PLGA microspheres: Effect of polymer source variation and temperature. Journal of Controlled Release. 2022, 347:347–355. https://doi.org/10.1016/j.jconrel.2022.05.014
  31. Yenduri, A.P. Costa, X. Xu, D.J. Burgess. Impact of critical process parameters and critical material attributes on the critical quality attributes of liposomal formulations prepared using continuous processing. Int. J. Pharm. 2022, 619:121700. https://doi.org/10.1016/j.ijpharm.2022.121700
  32. Duran, A. Costa, A. Gupta, X. Xu, H. Zhang, D.J. Burgess, B. Chaudhuri. Coarse-Grained Molecular Dynamics Simulations of Paclitaxel-Loaded Polymeric Micelles. Molecular pharmaceutics. 2022, 19(4):1117-1134. https://doi.org/10.1021/acs.molpharmaceut.1c00800
  33. Li, B. Wan, R. Jog, A. Costa, D.J. Burgess. Pectin microparticles for peptide delivery: Optimization of spray drying processing. Int. J. Pharm. 2022, 613:121384. https://doi.org/10.1016/j.ijpharm.2021.121384
  34. S. Fanse. Q. Bao. Y. Zou. Y. Wang. D.J. Burgess. Impact of polymer crosslinking on release mechanisms from long-acting levonorgestrel intrauterine systems. Int. J. Pharm. 2022, 612:121383. https://doi: 10.1016/j.ijpharm.2021.121383
  35. He, E. Renard, P. Lord, D. Cohen, B. Gu, X. Wang, G. Yenduri, D.J. Burgess. Strategies for extended lifetime of implantable intraperitoneal insulin catheters. J. Controlled Release. 2022, 341:487-497. https://doi.org/10.1016/j.jconrel.2021.11.038
  36. Wan, Q. Bao, Y. Zou, Y. Wang, D.J. Burgess. Effect of polymer source variation on the properties and performance of risperidone microspheres Int. J. Pharm. 2021, 610:121265. https://doi.org/10.1016/j.ijpharm.2021.121265
  37. Fanse, Q. Bao, Y. Zou, Y. Wang, D.J. Burgess. Effect of crosslinking on the physicochemical properties of polydimethylsiloxane-based levonorgestrel intrauterine systems. Int. J. Pharm. 2021, 609:121192. https://doi.org/10.1016/j.ijpharm.2021.121192
  38. Wang, D.J. Burgess. Drug release from in situ forming implants and advances in release testing. Advanced Drug Delivery Reviews, 2021, 178:113912. https://doi.org/10.1016/j.addr.2021.113912
  39. He, E. Renard, P. Lord, D. Cohen, E. Cem-Duranty, J. Place, B. Gu, X. Wang, G. Yenduri, D.J. Burgess. Root cause determination of intraperitoneal catheter obstructions: Insulin amyloid aggregates vs foreign body reaction. J. Controlled Release. 2021, 336:1-15. https://doi.org/10.1016/j.jconrel.2021.06.005
  40. B Wan, J.V. Andhariya, Q Bao, Y Wang, Y Zou, J. Burgess. Effect of polymer source on in vitro drug release from PLGA microspheres. Journal of Pharmaceutics, 2021, 607. https://doi.org/10.1016/j.ijpharm.2021.120907
  41. Gupta, A.P. Costa, X. Xu, and D.J. Burgess. Continuous processing of Paclitaxel polymeric micelles. Int. J. Pharm. 2021, 607:120946. https://doi.org/10.1016/j.ijpharm.2021.120946
  42. Sansare, T. Duran, H. Mohammadiarani, M. Goyal, G. Yenduri, A. Costa, X. Xu, T. O’Connor, D.J. Burgess, B. Chaudhuri. Artificial neural networks in tandem with molecular descriptors as predictive tools for continuous liposome manufacturing. Int. J. Pharm. 2021, 603:120713. https://doi.org/10.1016/j.ijpharm.2021.120713
  43. Ochi, B. Wan, Q. Bao and D.J. Burgess. Influence of PLGA molecular weight distribution on leuprolide release from microspheres. Int. J. Pharm. 2021, 599:120450. https://doi.org/10.1016/j.ijpharm.2021.120450
  44. Bao, Y. Zou, Y. Wang, S. Choi, D.J. Burgess. Impact of formulation parameters on in vitro release from long-acting injectable suspensions. The AAPS Journal, March 2021, 23:42. https://doi.org/10.1208/s12248-021-00566-0
  45. Li and D.J. Burgess. Biomarker monitoring and long-acting insulin treatment in a stress model to facilitate personalized diabetic control. Journal of Controlled Release. 2021, 332:21–28. https://doi.org/10.1016/j.jconrel.2021.02.013
  46. Li, R.V. Lalla, and D.J. Burgess. Enhanced drug loading of in situ forming gels for oral mucositis pain control. Int. J. Pharm. 2021, 595:12022. https://doi.org/10.1016/j.ijpharm.2021.120225
  47. S. Suh, M. Kastellorizios, N. Tipnis, Y. Zou, Y. Wang, S. Choi, and D.J. Burgess. Effect of implant formation on drug release kinetics of in situ forming implants. Int. J. Pharm. 2021, 592:120105. https://doi.org/10.1016/j.ijpharm.2020.120105
  48. Tipnis, M. Kastellorizios, A. Legassey, F. Papadimitrakopoulos, F. Jain, D.J. Burgess. Sterilization of drug-loaded composite coatings for implantable glucose biosensors. J Diabetes Science and Technology. 2021, 15(3)646-654. https://doi.org/10.1016/j.jconrel.2019.10.01410.1177/1932296819890620
  49. Lu, B. Ning, N. Fotaki, S.S. Sharp, D.J. Burgess and S. Haddouchi. American Association of Pharmaceutical Scientists (AAPS) and Chinese National Institutes for Food and Drug Control (NIFDC) joint workshop on dissolution, bioequivalence, product performance, and quality. Dissolution Technologies, May 2020. https://dx.doi.org/10.14227/DT270220P42
  50. Li, D.J. Burgess. Nanomedicine based drug delivery towards tumor biological and immunological microenvironment. ACTA PHARM SIN B. 2020, 10(11):2110-2124. https://doi.org/10.1016/j.apsb.2020.05.008
  51. Bao, M.D. Morales-Acosta, D.J. Burgess. Physicochemical attributes of white petrolatum from various sources used for ophthalmic ointment formulations. Int. J. Pharm. 2020, 583:119381. https://doi.org/10.1016/j.ijpharm.2020.119381
  52. Gupta, A.P. Costa, X. Xu, S.L. Lee, C.N Cruz, Q. Bao, D.J. Burgess. Formulation and characterization of curcumin loaded polymeric micelles produced via continuous processing. Int. J. Pharm. 2020, 583:119340. https://doi.org/10.1016/j.ijpharm.2020.119340
  53. Kohno, J.V. Andhariya, B. Wan, Q. Bao, S. Rothstein, M. Hezel, Y. Wang, D.J. Burgess. The effect of PLGA molecular weight differences on risperidone release from microspheres. Int. J. Pharm. 2020, 582:119339. https://doi.org/10.1016/j.ijpharm.2020.119339
  54. Li, Q. Bao, J. Shen, R.V. Lalla, D.J. Burgess. Mucoadhesive in situ forming gel for oral mucositis pain control. Int. J. Pharm. 2020, 580:119238. https://doi.org/10.1016/j.ijpharm.2020.119238
  55. P. Tipnis, J. Shen, D. Jackson, D. Leblanc, D.J. Burgess. Flow-through cell-based in vitro release method for triamcinolone acetonide poly (lactic-co-glycolic) acid microspheres. Int. J. Pharm. 2020, 579:119130. https://doi.org/10.1016/j.ijpharm.2020.119130
  56. Bao. Y. Zou. Y. Wang S. Choi. D.J. Burgess. Impact of product design parameters on in vitro release from intrauterine systems. Int. J. Pharm. 2020, 578:119135. https://doi.org/10.1016/j.ijpharm.2020.119135
  57. Bao. Y. Zou, Y. Wang, D. Kozak, S. Choi, D.J. Burgess. Drug release testing of long-acting intrauterine systems. J. Controlled Release. 2019, 316:349–358. https://doi.org/10.1016/j.jconrel.2019.11.015
  58. V. Andhariya, R. Jog, J. Shen, S. Choi, Y. Wang, Y. Zou, D.J. Burgess. In vitro-in vivo correlation of parenteral PLGA microspheres: Effect of variable burst release. J. Control Release. 2019, 314:25-37. https://doi.org/10.1016/j.jconrel.2019.10.014
  59. V. Andhariya, R. Jog, J. Shen, S. Choi, Y. Wang, Y. Zou, D.J. Burgess. Development of level A in vitro-in vivo correlations for peptide loaded PLGA microspheres. J. Controlled Release, 2019, 308: 1-13. https://doi.org/10.1016/j.jconrel.2019.07.013
  60. Wang, N. Meng, S. Wang, Y. Zhang, L. Lu, R. Wang, H. Ruan, K. Jiang, H. Wang, D. Ran, C. Zhan, K. Yu, D.J. Burgess, W. Lu. Non-immunogenic, low-toxicity and effective glioma targeting MTI-31liposomes. J. Controlled Release. 2019, 316:381–392. https://doi.org/10.1016/j.jconrel.2018.12.003
  61. R. Pace, R. Jog, D.J. Burgess, M.K. Hadden. Formulation and evaluation of itraconazole liposomes for Hedgehog pathway inhibition. Journal of Liposome Research. 2019, Oct 2:1-7. https://doi.org/10.1080/08982104.2019.1668011
  62. V.Andhariya, J. Shen, Y. Wang, S. Choi, D.J. Burgess. Effect of minor manufacturing changes on stability of compositionally equivalent PLGA microspheres. Int. J. Pharm. 2019, 566:532-540. https://doi.org/10.1016/j.ijpharm.2019.06.014
  63. Jog, D.J. Burgess. Comprehensive quality by design approach for stable nanocrystalline drug products. Int. J. Pharm. 2019, 564:426-460. https://doi.org/10.1016/j.ijpharm.2019.04.050
  64. Cui, C.M. O’Connell, A. Costa, Y. Pan, J.A. Smyth, Paulo, H. Verardi, D.J. Burgess, Herbert J. Van Kruiningen, A.E. Garmendia. A PRRSV GP5-Mosaic vaccine: Protection of pigs from challenge and ex vivo detection of IFNγ responses against several genotype 2 strains. PLos One. 2019, 14(1):e0208801. https://doi.org/10.1371/journal.pone.0208801
  65. Wang, H. Wang, K. Jiang, Y. Zhang, C. Zhan, M. Ying, M. Zhang, L. Lu, R. Wang, S. Wang, D.J. Burgess, H. Wang, W. Lu. Liposomes with cyclic RGD peptide motif triggers acute immune response in mice. J. Controlled Release. 2019, 293:201–214. https://doi.org/10.1016/j.jconrel.2018.12.003
  66. Bao, D.J. Burgess. Perspectives on physicochemical and in vitro profiling of ophthalmic ointments. Pharmaceutical Research. 2018, 35:234. https://doi.org/10.1007/s11095-018-2513-3
  67. Jog, D.J. Burgess. Nanoamorphous drug products — design and development. Int. J. Pharm. 2018, 553:238-260. https://doi.org/10.1016/j.ijpharm.2018.10.046
  68. Gu, F. Papadimitrakopoulos, D.J. Burgess. PLGA microsphere/PVA hydrogel coatings suppress the foreign body reaction for 6 months. J. Controlled Release. 2018, 289:35-43. https://doi.org/10.1016/j.jconrel.2018.09.021
  69. Bao, Bing Gu, Claire F. Price, Yuan Zou, Yan Wang, Darby Kozak, Stephanie Choi, D.J. Burgess. Manufacturing and characterization of long-acting levonorgestrel intrauterine systems. Int. J. Pharm. 2018, 550:447–454. https://doi.org/10.1016/j.ijpharm.2018.09.004
  70. Bao, B. Newman, Y. Wang, S. Choi, D.J. Burgess. In vitro and ex vivo correlation of drug release from ophthalmic ointments. J. Control Release. 2018, 276:93–101. https://doi.org/10.1016/j.jconrel.2018.03.003
  71. Tipnis and D.J. Burgess. Sterilization of implantable polymer-based medical devices: A review, Int. J. Pharm. 2018. 544:455-460. https://doi.org/10.1016/j.ijpharm.2017.12.003